Sentence examples for in the context of modifications from inspiring English sources
These are interpreted in the context of modifications of the controls on weathering processes, leading to enhanced understanding of the processes themselves.
For analysis of gene expression in the context of histone modifications, only genes represented on the Agilent and Nimblegen arrays were considered.
The use of HSA as a biomarker has primarily been described in the context of electrophilic modifications at Cys34.
Understanding turnover in the context of histone modifications and sequence variants could provide valuable additional insight into the function of histone replacement.
Another important aspect to be considered in the context of genetic modification is the potential for lethal or toxic effects of modifications per se.
This phenomenon has largely been studied in the context of chromatin modification.
R79, for example, which hydrogen-bonded to the phosphate backbone in the context of non-modification, dissociated from DNA after 16 ns (Fig. S5).
The impact of electrophiles has long been studied in the context of covalent modification of DNA and its potential to lead directly to mutations.
The importance of lysine acetylation is well appreciated in the context of nuclear histone modifications (Strahl and Allis, 2000), but the regulatory implications of the modification extend beyond gene regulation.
This suggests that high levels of H3-K27me3 may lock in the repressed state of Sox1 in NS cells while lower levels may still allow its up-regulation at day 8, confirming that the H3-K27me3 status contributes to transcriptional output only in the context of other histone modifications and regulatory inputs.
In gene therapy, chromatin interaction may be decisive for the insertional risk profile and the likelihood of long-term expression of the therapeutic gene; in the context of HIV, chromatin modifications have been identified as a major mechanism that establishes and controls viral latency, thus representing a major obstacle towards the holy grail of HIV eradication (Colin & Van Lint, 2009).
