Clearly, the disruption of the actin cytoskeleton at the level produced by sAB-27 is lethal to the cell making it a potential therapeutic agent in the context of its internalization via the SP/NK1 pathway, which demonstrates higher specificity for cancer versus normal tissue.
In the context of prion disease, RPSA is needed for the internalization and propagation of prion proteins [ 2].
In the present study, we employed engineered cells to study these internalization-related processes in the context of the two melatonin receptors, MT1 and MT2.
TTR receptors have been invoked for the internalization of soluble WT TTR in the context of normal catabolism in hepatocytes, and T4 transport in astrocytoma, chicken oocytes and ependymoma cells, although none has been identified [ 43, 45– 45].
β-Arrestins, originally discovered in the context of heterotrimeric guanine nucleotide binding protein coupled receptor (GPCR) desensitization, also function in internalization and signaling of these receptors.
To date the relationship between receptor internalization and in vivo tolerance has largely been debated in the context of the mu opioid receptor, where morphine tolerance represents a major clinical limitation (see [40]).
In the context of rituximab, a type I anti-CD20 monoclonal antibody, the lysosome is the ultimate destination for FcγRIIB-promoted internalization of CD20 anti-CD20 CD20 anti-CD20ing to reducomplexesssion of CD20 on the celeadingace, toereducedntributing to rituximab rexpression
The previously reported defects in autophosphorylation may not be relevant in the context of the active variant of the receptor in which point mutations permit ligand-independent receptor activation and inhibit the receptor downregulation via internalization.
In the context of PALM, this method was applied to investigate the co-localization between pamCherry-labeled clathrin-coated vesicles and psCFP2-labeled GPCRs during internalization (Shivanandan et al. 2013), as illustrated in Fig. 5.
Whilst the latter studies clearly indicate an involvement of Rab5 in internalization/trafficking of certain GPCRs, in the broader context of the superfamily, to date it is in no way a widely recognized phenomenon or indeed predictable.
