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Given the common roles of the BRCA gene products in genomic maintenance, this suggests that phenotypic differences between BRCA1- and BRCA2-associated tumours impose selective advantages for distinct genomic alterations in the context of instability generated by BRCA-deficiency.
In light of the common roles for BRCA1 and BRCA2 in genomic maintenance, this suggests that the observed phenotypic differences impose selective advantages for genomic alterations at distinct regions in the context of instability generated by BRCA-deficiency.
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CRRT for refractory metabolic acidosis in the context of cardiac instability is used in the critically ill patient as an adjunct strategy and is applied earlier than CRRT initiated for other indications.
This is evidenced by the success of the RH voucher programme in Yemen in enabling more women to access a basket of reproductive and maternal newborn health services in the context of increasing instability, a much higher than expected number of institutional deliveries (by a factor of at least 25%) in 1 year of the crisis.
In the context of political instability, tobacco companies seize the opportunity of lack of tobacco control.
Furthermore, Neil1 repairs oxidative lesions in ssDNA and bubble structures, which might be important DNA structures in the context of TNR instability (16).
Studies should also consider the roles of ethnic minority position and international immigration in the context of residential instability following psychosis onset.
See for example, [ 61] in which the authors discuss the combination of ODEs for chemokine receptor internalisation with agent-based models of lymphocytes in the context of tissue instability in arthritis.
Other resistance mechanisms include enhanced DNA repair, loss of p53, inhibition of apoptosis, activation of cell survival pathways caused by mutations or epigenetic alterations occurring in the context of genetic instability (selection of resistant cells) [ 6].
The serrated pathway shown in about 15% of the colorectal carcinomas demonstrates BRAF mutation and methylation/silence of the MLH-1 mismatch repair complex in the context of microsatellite instability [ 34].
The second experiment demonstrates the mixing layer resonance in the context of a fluidelastic instability causing high-amplitude vibrations in gas turbine high-pressure compressor rotor blades.
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