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Lev (2005) describes how the DSM does not allow for a healthy, functioning variant of transgenderism, and only categorises transgender experience in the context of dysfunction [ 21].
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In this review, I will discuss neurodegenerative diseases in the context of nuclear dysfunction and, more specifically, alterations in nuclear bodies.
The α1-AR blockers have not been studied in detail in the context of diastolic dysfunction.
It is not known, whether acute inflammatory conditions are altered in the context of telomere dysfunction.
Our results indicate that pancreatic regeneration is limited in the context of telomere dysfunction without evidence for p53 checkpoint activation.
In the context of mitochondrial dysfunction and metabolism, Ets-1 was found to at least partially down-regulate several components of the electron transport chain.
In the context of telomere dysfunction, heterozygous deficiency of SOD2 does not further accelerate aging.
The latter is particularly noted in the context of renal dysfunction, with concomitant anaesthesia posing a particular risk.
Ryu et al. found that miR-126 was upregulated in the context of mitochondrial dysfunction in SK-Hep-1 (hepatic cancer) cells, and reduced expression of IRS-1.
Although a general inhibition of TIM23 would be detrimental, these findings suggest that a slight modulation of its activity could be beneficial in the context of mitochondrial dysfunction.
In the context of diastolic dysfunction, it is striking that many mechanisms activated by an increased generation of ROS lead to reduced availability of energy.
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