Aberrant expression of chemokines and their receptors, adhesion molecules, and matrix metalloproteinases in the context of HIV contribute to the transmigration of leukocytes across the blood brain barrier, exacerbated CNS inflammation, and HIV replication within the brain (see Figure 1).
The collaborative nature of the project, especially in the context of state opposition, contributes significantly to the formation of a shared sense of purpose among the wide variety of intellectuals who belong to the French Enlightenment.
Despite the limitations and uncertainties that these constraints and considerations place on the interpretation of the results, the data are at a minimum consistent with a number of broad interpretations and, in the context of other work, contribute to a more detailed model of lupus immunopathogenesis as follows.
Future studies may successfully identify a transcription factor that can bind to a methylated motif in the context of chromatin and contribute to gene silencing.
Genetic variation in the context of a GRN contributes to phenotypic differences in complex traits [ 41, 80– 85] and natural variation is a powerful tool to expand knowledge of GRNs [ 24, 25, 82].
5 There is no methodology that is "better" than another in some abstract sense; the methodologies are all to be viewed in the context of how they contribute to our overall goals of acquiring knowledge and our ability to use them to draw valid inferences.
As stated by Kazdin, There is no methodology that is "better" than another in some abstract sense; the methodologies are all to be viewed in the context of how they contribute to our overall goals of acquiring knowledge and our ability to use them to draw valid inferences.
Although is still early to fully understand the KLF6 function in tumorigenesis, results of this work suggest that the tumor suppressor function described for KLF6 could be recruited and/or subverted in the context of breast cancer environment, contributing to tumor development.
The study design will enable a more consistent analysis on the degree of protection from prophylaxis before and after sexual exposure in the context of healthcare clinics, thus contributing to prevention programmes.
It is likely that selective pressure in the context of reproductive fitness contributes to the evolution of novel isozymes in this pathway.
