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In the case of validating ensemble models, the ANN-SVM had the highest AUC of all (0.826), followed by ANN-MaxEnt (0.803), SVM-MaxEnt (0.792), and ANN-MaxEnt-SVM (0.811).
As a result, in the case of validating models separately, ANN gained the highest area under the curve (AUC) with a value of 0.824, followed by SVM (0.819), and MaxEnt (0.75).
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In this work a solution is proposed for the specific case of validating analytical methods involved in the assessment of the content uniformity or uniformity of dosage units of a batch of pharmaceutical drug products as proposed in the European or US pharmacopoeias.
The strategy adopted included (a) in vitro biological assays, against eel AChE (EeAChE) and equine serum BuChE (EqBuChE) in order to determine the compounds IC50 and their dose-response activity, consolidated by (b) molecular docking studies to evaluate the docking poses and interatomic interactions in the case of the hit compounds, validated by STD-NMR studies.
In the case of paralogs present, we validated inferred orthologies by phylogenetic reconstruction (supplementary fig. S6, Supplementary Material online).
However, in the case of OA, no known (validated) early diagnostic test exists that can either predict the onset or eventual severity of the disease.
> > > > The AUC and AUPR scores of BASELINE were relatively high regardless of fingerprints in the case of single reactions, which validated the fact that a core substructure is conserved between a substrate and a product in a reactant pair.
The predicted phase stability regions and the broad dual-phase transition regions in the case of Zr1−xAlxN and Hf1−xAlxN are validated by experiments.
First, the method is validated in the case of surface piercing hydrofoil.
This procedure is validated in the case of high swirled confined natural gas diffusion flames.
The results obtained are validated in the case of an isotropic layer for spherical and conical indenters.
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