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The corresponding text is in the aforementioned subsection.
We have made revisions to make these points more clear and explicit in the text (in the aforementioned subsection).
We have now included this figure as Figure 8 figure supplement 4 and a short discussion in the aforementioned subsection of the Results.
Accordingly, we have emphasized the correlative nature of our argument in the aforementioned subsection and indicated a possible role of RelB in other cell-types in pathogen response.
5) In the aforementioned subsection, it is claimed that: "the number of accessible mutational trajectories that lead to a wild-type level fitness peak from AE are highly limited".
Multiple studies support that clustering mediates digital activation in NF-κB signaling (discussed in the aforementioned subsection) though we discuss other cases where additional factors may contribute (Introduction, first paragraph).
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These new data are now added in the manuscript (see the aforementioned subsection) and illustrated in Figure 3 figure supplement 1. 4) There is no clear demonstration that the effects of leak K + and Na + are two separate effects.
For example, one of the reviewers struggles greatly with the authors defining shear in terms of "the negative change in average triangle elongation" (in the third paragraph of the aforementioned subsection and then seemingly contradicted in the fourth paragraph).
However an alternative explanation is that instead of losing many of these so called 'core' genes, they have simply undergone significant sequence divergence in the apicomplexan lineage, which might not be so surprising given the considerable changes in host tropism, life cycle, morphology etc. (in the first paragraph of the aforementioned subsection).
This statement, repeated in the last paragraph of the aforementioned subsection, should also be removed.
b) In the fifth paragraph of the aforementioned subsection, neither initial nor boundary conditions are stated.
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