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Crystal structure analyses showed that while selectivity in the B chain is achieved entirely through van der Waals repulsion, the best selectivity in the A chain is obtained for the variant with the lowest number of atoms in the interface, thus possibly leading to underpacking of the dimer interface.
We identified K166 in the A chain and K166 in the B chain of α-crystallin as major glycation sites during the in vitro reaction.
It has a continuous ATP-binding region of "G-G-C-H-R" located at residues 81~ 85 in the A chain.
We found also two in vivo glycated lysine residues: K92 in the B chain and K166 in the A chain, which are known as locations for Amadori products.
Insulin contains two chains A and B that are linked by two disulfide bonds, and there is an additional intrapeptide disulfide bond in the A chain (structure shown in Figure 2a, inset).
All amino acid side chains were protected by trifluoroacetic acid (TFA -labile proTFA -labileuprotectingfor Cys8 (But) and Cys21 (Acm) in the A chain, and Cys19 (Acm) in the B chain.
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This strand forms an anti-parallel sheet with the strand A2 in the A-chain.
120 Human insulin and bovine insulin differ by only three amino acids (two in the A-chain and one in the B-chain) 121, 122 and antibodies that bind to bovine insulin can crossreact with human insulin.
The last time I saw Ruqayah was in the summer of 2014, in a chain cafe in Cairo's largest shopping mall.
Mr. Grande's decision, made in late May, was reported yesterday in the Brooklyn Papers, a chain of weeklies.
In the evening a chain of over 100 beacons will be lit across the UK.
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