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Objective: To evaluate the messenger RNA (mRNA) expression of hspA2 in testes of infertile men with azoospermia.
Although both aromatase activity and CYP19 mRNA were clearly detectable in testes of X. laevis, both aromatase enzyme activity and CYP19 gene expression were very low.
Histologically, marked changes were noticed in testes of PTU-treated mice; immunohistochemical and western blot analyses of testes in treated mice also revealed marked decrease in the expression of THRα1 at both age groups.
To determine whether the transcription factors liver X receptors (LXRs) and their downstream genes, which are involved in the regulation of several testicular functions in mouse models, are differentially expressed in testes of men with nonobstructive azoospermia (NOA) or obstructive azoospermia (OA).
Our data indicated significant increases in lipid peroxides (LPO), total peroxides and superoxide anion levels in testes of rats treated with CP (2 mg/kg/week, for 4 weeks) that was associated with a significant reduction in the activity of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT) and glutathione S-transferase (GST).
Nanog transcripts and protein were detected in testes of mouse, dog, pig, and human.
In the current study, NANOG expression was examined in testes of various mammals, including mouse and human.
An important aspect of our results is that we do not observe the complete breakdown of this spermatogenesis regulatory pathway in testes of sterile hybrids.
Together, the higher expression in testes of TERC and H/ACA box snoRNAs suggests that these factors are essential for germ cell proliferation and maintenance.
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Next, we examined eGFP expression in testes sections of TNG mice.
Treatment-associated changes were observed in the testes of all males in this study.
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