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Formation of androstanediol was normal in testes from mice deficient in steroid 5α-reductase 2 but absent in testes from mice deficient in steroid 5α-reductase 1, indicating that isoenzyme 2 is not expressed in day 24 26 testes.
Oteiza, P. L., Olin, K. L., Fraga, C. E. & Keen, C. L. Oxidant defense systems in testes from zinc-deficient rats (44040).
This enzyme is detectable in testes from rats 6-54 days of age.
There is only a 1.1-fold activation by FSH in testes from mature (34 days old) animals.
Sertoli cell-only tubules were detected in testes from mice lacking expression of ERCC1 or MSH2 but not p53.
As it has been described in the brain, the Western blot analysis revealed that the amount of αSNAP was strongly reduced in testes from SP mice.
Similar(31)
Since this type of defect was infrequent and never observed in testes taken from pupal stages, we interpret them as resulting from a failure in the maintenance of the axoneme structure, rather than defects in the assembly process.
In addition, real-time PCR results also revealed a significant downregulation of miR-383 expression in testes obtained from all five NOA patients compared with normal controls.
When expression was examined under higher magnification, fluorescence was observed in regions occupied by primary spermatocytes [ 35] and at greater intensity in regions carrying secondary spermatocytes, spermatids and mature spermatozoa in testes dissected from heterozygous α-tubulin:eGFP lines.
Administration of CCl4 significantly (p < 0.05) increased the level of MDA in the testes from 0.68 ± 0.08 μmol/L in control group to 1.60 ± 0.30 μmol/L in the treated group.
Our data confirm markedly decreased Cldn3 transcript levels in SCARKO testes from day 15 onwards but also show that differences in transcript levels of other tight junction elements such as Cldn11 and Jam3 are already evident at a much earlier time points (days 4 and 10 respectively) [23].
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