Surprisingly, sponsors proposed 18 new fish tests for chemicals that met the Kow criteria for use of Daphnia data, and the U.S. EPA accepted 16 of these test proposals, although sponsors subsequently dropped 6 of the proposed fish tests in test plan revisions.
Even though Microsoft gets only $200 million in yearly revenue from Korea, it has just invested $500 million in Korea Telecom, in part to test plans for ubiquitous computing.
It also highlights the benefits of using prior information in order to locate critical spots in the design and in subsequent development of test plans.
For each health and environmental effect end point potentially requiring animal test data, we determined whether new animal testing was proposed in original test plans and if not, which of the animal-saving measures listed in Table 1 was used to satisfy the end point.
In revised test plans submitted by sponsors, we noted whether or not they agreed to make the changes recommended by the U.S. EPA.
Of the 334 tests proposed by sponsors in original test plans, the U.S. EPA accepted 223, rejected 49 as not needed, and substituted 62 tests that used fewer or no animals (Table 3).
In addition, the ACC acknowledged in its test plan that these substances consist of neutral organic hydrocarbons, whose toxic mode of action is well understood to be nonpolar narcosis.
In the current study, we present a cumulative assessment program in which test planning, repeated testing and compensation are combined in order to influence study effort.
Sponsors proposed these much more often than separate tests, and the U.S. EPA, in its test plan reviews, went on to recommend them in place of nearly all the separate tests proposed.
Nevertheless, contemporary test management procedures lack of methodological support, especially in the field of test planning.
Also, embedded systems often have unique characteristics that should be reflected in the test plan.
