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The pseudo-dynamic method is an alternative to dynamic analysis of structures, here offering to the researcher the possibility of examining with detail the specimen in test for the initiation and progress of eventual damage mechanisms arising in the beam element joints whenever included in the design.
†In test for homogeneity with categorisation in three (appendicitis, mesenteric lymphadenitis, other disease) or six (appendicitis with perforation, appendicitis without perforation, mesenteric lymphadenitis, appendiceal disease except appendicitis, unspecific abdominal pain, other and unspecified disease) groups of underlying disease.
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Despite its modest sensitivity the LAM ELISA is an accurate rapid rule-in test for TBM that has incremental value over smear-microscopy.
In summary, this study suggests that a standardised LAM antigen detection assay is a useful rapid rule-in test for TBM in HIV-infected individuals with advanced immunosuppression.
Thus urine LAM is a reasonable rule-in test for active TB in those with a CD4 count <200 cells/mm3 (sensitivity = 37% and specificity = 95%).
Firstly a newly developed clinical prediction rule, suited to resource-poor high HIV prevalence settings, is a useful rule-in test for the rapid diagnosis of TBM.
The high specificty of the assay thus makes urine LAM a potential rule-in test for active TB within this sub-group.
We recently showed that CSF antigen-specific quantitative T cell assays may be a rapid and accurate rule-in test for TBM but the available ELISPOT assay (T SPOT TB) is expensive and requires overnight processing [13].
Secondly, LAM antigen, which has not previously been prospectively evaluated in CSF, is useful as a rapid rule-in test for the diagnosis of TBM in HIV-infected individuals with advanced immunosuppression.
Polymerase chain reaction (PCR), which may be used as a confirmatory test for TBM [11], is a good rapid rule-in test for TBM with a sensitivity of ∼40 to 50% but this technology is unavailable in most hospitals in Africa [12].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com