The ontology that been created will be able to represent the services in terms of class, subclass, instances, relationship and also the functionality of the services.
Apparently, the tracer properties in terms of OR subclass selectivity and agonistic/antagonistic character dominate the information that can be drawn from in vivo studies.
When we used our elastic-net analysis using only one class of genomic aberration (e.g. mutation alone, copy number alone), our results were highly concordant with the results of the TCGA study in terms of molecular subclass.
In terms of IgG subclasses, there is evidence implicating both IgG2a and IgG3 antibodies in the pathogenesis of renal disease in MRL/ lpr mice [ 6].
In this respect, Ab responses in terms of isotype and subclass will be influenced by the route and conditions under which KLH is administered.
When administered in distinct adjuvant formulations, antibody titers induced by the recombinant protein His6MSP119-PADRE were not significantly different to those generated by complete/incomplete Freund's adjuvant (CFA/IFA) in terms of magnitude, affinity, IgG subclasses and longevity.
MPI induced an immune response comparable to CFA in terms of antibody levels (total and subclasses), in vitro splenocyte activation (secretion of IFN- γ and IL-12), and protection against challenge in mice [ 173].
Murine IgG2a subclass was selected as this subclass is similar to hIgG1 in terms of FcγR binding, and hIgG1 has been the most commonly used subclass for anti-Aβ immunotherapy.
However, in terms of direction of the head rotation, subclass structures from the II-c and II-e groups are sharply different.
Further, the nature of the immune responses in terms of total IgG antibodies and their subclass distribution, T-cell proliferation and IFN-γ production, varied with the T-epitope and mouse strain, which may indicate the need for inclusion of a combination of different universal T-epitopes in a future malaria subunit vaccine.
Firstly, it might be that the antibodies differ between strains in terms of epitope specificity, affinity or IgG subclass.
