Since SUV is susceptible to spatial resolution and image noise, reconstruction conditions should be properly adjusted for each camera to provide reliable and robust SUVs in terms of the harmonization of SPECT/CT quantitation.
Despite their recently expanded use in clinical laboratories [6, 7, 8], it is yet unclear whether these more-sensitive automated third-generation IMAs have made improvements in terms of diagnostic accuracy and harmonization compared with previous methods [9, 10].
Therefore, we thought that SUVmax and SUVpeak are not suitable parameters for harmonization in terms of test-retest reproducibility.
This chapter reviews those efforts, in terms of their degree of maturity and harmonization, and how they relate to clinical decision support.
The UV method was validated according to the International Conference on Harmonization Guidelines [27] in terms of linearity, precision, accuracy, and limits of detection and quantitation for meropenem were established.
Harmonization may address the process in terms of the compounds to be monitored enabling quality assurance and proficiency testing arrangement between countries.
Thus, the less controversial path of gradual implementation (precluding a "big bang" harmonization) aims only at setting minimum thresholds in terms of health and safety.
The lack of harmonization of these criteria makes it difficult to establish priorities in terms of assistance and treatment in maternal and infant health, especially in countries with limited resources.
But a process of regulatory harmonization was initiated in 1985 so that what limited the common market in terms of economies of scale would disappear with the single market -- hence this whole enterprise of regulatory convergence, harmonization and mutual recognition.
