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In the present work the viability of integrated continuous mixing and compression processes for manufacturing of extended release (ER) matrix tablets was investigated in terms of dissolution behavior.
Microencapsulation, cyclodextrin inclusion and impregnation allow to incorporate poorly soluble materials in fast-dissolving hydrophilic excipients, leading to promising results in terms of dissolution rate enhancement.
The responses considered as output variables were energy spent on the extrusion, particle size distribution of the granules and the parameters of the Weibull function, time (τd) and shape, in terms of dissolution behavior.
The core activity of the QRED program was to perform dissolution tests on originator drugs approved before March 1995 by the NIHS and 10 prefectural health institutes, using several test media, and to match their generic products in terms of dissolution profile through formulation and process changes.
Our results demonstrate that the SIP exhibits markedly advantageous drug release performance in terms of dissolution time.
The particles were also characterized in terms of dissolution (in the presence or absence of serum) and zeta-potential (Supporting Information Table 1).
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More satisfactory results were obtained in terms of disintegration and dissolution time, mechanical properties, and mucoadhesive characteristics.
Reset transition and data loss are described in terms of the dissolution of a conductive filament, which is modeled by thermally-activated diffusion of defects/dopants.
We include mechanisms such as advection, diffusion, and water rock chemistry in terms of precipitation and dissolution, ion exchange, aqueous equilibrium of carbon species, complexes, and charge balance.
In the present investigation the effect of expression of eye cell lines [rabbit corneal epithelial cell line (SIRC)] on highly porous HAp scaffolds were compared with the normal fibroblastic cells on HAp in general, in terms of in vitro dissolution studies, cell culture cytotoxicity and cell adhesion properties.
The complex process of oral drug absorption is influenced by a host of drug and formulation properties as well as their interaction with the gastrointestinal environment in terms of drug solubility, dissolution, permeability and pre-systemic metabolism.
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in terms of surveillance
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