Expression of the cVAP-C also resulted in suppression of HCV replication in both the replicon and HCVcc infected cells.
To prove the role of stress induced by proteasome inhibition in suppression of VSV replication, we used wild type (wt) GCN2+/+ MEF and GCN2−/− MEF for VSV infection.
We then examined possible synergy of post-challenge passive NAb immunization with the prophylactic CTL-based vaccination in suppression of SIV replication in two groups of macaques possessing MHC-I haplotype 90-088-Ij and 90-120-Ia, respectively (Figure 4A).
Superinfection with hepatitis D is associated with higher progression rate to chronic disease and to serious complications [3], [2] and may result in suppression of HBV replication, such that an individual with dual infection transmits HBV less than an individual infected only with HBV [4], [5].
Superinfection with HCV can result in suppression of HBV replication, as well as termination of the HBsAg carriage [ 11].
Nevertheless, raltegravir's generally favorable safety profile and its superior potency in suppression of HIV-1 replication will likely ensure its place in the range of successful HIV-1 antiretroviral treatment options for years to come.
Since the anti-DHAV mechanisms of 1 and 2 in vitro probably involve suppression of replication and release, 2's better performance in anti-DHAV may result from its far more effectively inhibiting virus replication.
In this way both infected and nearby uninfected cells become nonpermissive to viral replication through expression of a host of diverse antiviral activities that lead to the suppression of replication of most viruses as well as other pathogens.
These results demonstrate for the first time that NSs is a bifunctional enzyme, which could participate in viral movement, replication or in suppression of the host defense mechanism.
