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In support of such a model, pharmacological inhibition of autophagosomal-lysosomal fusion using BafA causes a strong accumulation of autophagosomes, accompanied with APP and APP-CTF accumulation in those autophagosomes and other intracellular vesicles.
In support of such a model, we have also demonstrated that the ISG15 pathway is elevated not only in various A-T cell lines derived from A-T patients, but also in brain tissues of ATM knockout mice and A-T patients.
In support of such a model, next generation sequencing of 100 individual nuclei from a polygenomic, triple negative human breast tumor indicated punctuated clonal evolution [ 99].
In support of such a model, our data shows that phosphorylation of the Thr, Thr and Thr sites plays a critical role in mediating the release of matured PKCγ from the Hsp90α chaperone complex.
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There is strong evidence from studies in model organisms in support of such a concept.
In support of such work, a multimodal model is developed to characterize the device and the liner material.
Some recent studies can be interpreted in support of such model.
In support of such genetic models, studies of infectious disease susceptibility have commonly documented three key indicators of epistasis.
Some support for such a model has also been reported in a study of individuals with multiple sclerosis [ 8].
To perhaps provide support for such a model, we sequenced the tra1 allele 3′ of base 9730 in one of the intragenic suppressors of tra1 -F3744A.
The lack of chromosomal structural changes supports such a model of relatively recent, and rapid, diversification in this clade [ 69, 70].
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