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Search terms used in the review are shown in supplement file S1.
The details of the development of the model are shown in supplement file S2.
Randomised placebo controlled (RCT) trials of IPTi were identified by literature search using the strategy shown in supplement file S1.
Furthermore, we have added a section in Supplement file 1 ("Initial conditions") detailing the initial conditions, and we have extended the section "In silico predictions" to describe techniques used for simulations based on posterior parameter distributions.
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The detailed data quality control procedures are presented in the Online Supplement File 1.
A detailed description of the biochemical reactions in the different networks is given in the supplement files.
Additional scans were performed for -10 and -35 promoter sequences as described in Supplement, Additional file 1.
An example of plug-in script that uses Openbabel [17] for opening PDB file is given in supplement [see Additional file 2].
The mean change of transcripts from a particular pathway is summarized in Figure 5, and data from the individual sequences can be found in supplements (Additional file 5: Table S4).
All data were included in the main manuscript and supplement files.
An example of luscus file format is given in supplement [see Additional file 1].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com