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There is a growing need to employ primary cells in such screenings, since they reflect the physiological situation more closely than transformed cell lines do.
While mutants with severe growth defects can be easily detected in such screenings, it has been difficult to detect single-gene deletion mutants which grow faster than the wild type, as the difference in growth rate can be small and below the threshold of detection.
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The task force recommends against screening for prostate cancer in men 75 and older, and screening for cervical cancer in women 65 and older who have had a previous normal Pap smear, but Medicare spent more than $50 million in 2008 on such screenings, as well as additional money on unnecessary procedures that often follow.
In the past they have hung a large muslin sheet in their backyard for such screenings.
"The issues are similar to what a lot of us are coping with," said an approving Garett Reppenhagen, an Iraq veteran who saw "Valley of Elah" last week at one of the first such screenings in Washington.
Between 2009 and 2012, investigators completed 1,510 such screenings in 49 countries.
What is beyond doubt is that such screenings allow many people to see – albeit not in their original form – fine productions and fine performances.
At least eight states mandate such screenings.
Such screenings may be particularly important for survivors who develop late medical morbidities that result in reduced health status.
Community-based screenings may be a reasonable strategy to target such populations, but significant challenges must be overcome to make such screenings feasible and cost-effective.
Doctors normally recommend such screenings every five years.
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