Sentence examples for in such alterations from inspiring English sources

The nucleus accumbens is critically involved in the locomotor activation produced by psychostimulants and in the augmentation of this effect observed upon repeated drug administration (i.e. behavioral sensitization), although there is not a general consensus as to whether the nucleus accumbens-core or the nucleus accumbens-shell is preferentially involved in such alterations.

This is partially due to the fact that these techniques have a relatively limited resolution which hampers identification of the specific cancer-associated genes recurrently targeted in such alterations.

There is increasing evidence in the literature that the inflammatory response plays an important role in such alterations in gastrointestinal cancer patients [ 8, 9].

A variety of mechanisms seems to be involved in such alteration: in order of frequency, the downregulation of FAS, the deregulation of other members of the pathway and the occurrence of mutations at the FAS-coding sequence.

Our aim at this study is to determine whether FAS-mediated apoptotic signaling is compromised in human T-LBL samples and the mechanism or mechanisms involved in such alteration.

A variety of mechanisms seems to be involved in such alteration, in order of frequency the downregulation of FAS, the deregulation of other members of the pathway and the occurrence of mutations at FAS. Considering these results together, it seems plausible to think of a cumulative effect of several alterations in each T-LBL, which in turn may result in FAS/FASLG system deregulation.

This can be considered as a further prediction of the model, that could in principle be tested experimentally if such alterations in flower meristem geometry could be achieved.

It is now known that micro RNAs (miRNA) can have a role in mediating such alterations in gene expression through repression or degradation of target mRNAs.

In fact, such alterations in metabolism and physiology have been shown to predispose the fetus to multiple metabolic, endocrine, cardiovascular, mental, and cognitive disorders in adult life [ 10, 11].

Accurate chromosome segregation is essential to prevent aneuploidy; in mitosis, such alterations in chromosome number are associated with cancer and tumor progression and in meiosis with miscarriage and birth defects (Siegel and Amon 2012; Duijf and Benezra 2013; Jones and Lane 2013; Ricke and van Deursen 2013).

In contrast, such alterations were rare in tumors arising in younger children, supporting the existence of age-related pathways of tumorigenesis in childhood.