Sentence examples for in substantial dose from inspiring English sources

FN can result in substantial dose reductions and delays to chemotherapy cycles that may jeopardise treatment outcomes, prolonging patient recovery, and diminish the success of antineoplastic therapy [ 5- 7].

One popular current theory is that the switch to lead-free petrol has reduced ingestion of a substance, which in substantial doses over a long period has known links to aggression.

These delicious grapefruit varieties are a textbook example of how crops were genetically modified back in the 1960s and '70s using a method called "mutagenesis breeding". Basically, seeds (or in this case pieces of budwood) were exposed to gamma radiation in substantial doses, and then sifted through to find ones with mutations to their DNA that had desirable qualities.

In contrast, BEZ235 treatment resulted in substantial dose-dependent accumulation in the G0-G1 phase of the cell cycle.

Addition of heparanase to the culture medium resulted in a substantial, dose dependent decrease in ConA activation and proliferation of the spleen cells (Fig. 3A).

In addition substantial dose reduction can be assumed for both the maternal breasts and the fetus.

Exposing cultured PBMCs to either GOS or GOS/FOS fractions resulted in a substantial dose-dependent increase of tumour necrosis factor-α (TNF-α) production in LPS challenged PBMCs.

Current guidelines for fenofibrate use in Western countries recommend a substantial dose reduction (between 30 and 69%) when renal function is impaired but with significant variation in the threshold at which this should be implemented.

Although some studies have shown that substantial dose reduction in CT-colonography is feasible [ 5, 6], an alternative imaging method that does not require ionising radiation would be preferable, especially for screening purposes.

We co-expressed Aurora-A (1 µg) with different amounts of PUM2, and immunoblotting analysis revealed that the increase in the protein amount of Aurora-A was accompanied by a substantial dose dependent increase in the steady-state protein amount of PUM2 (Figure 3A).

In immunology, parts-per-billion is a substantial dose.