However, this over-representation of initial frame disruptions in the 'non-NMD' region also arises for the subsets of transcripts in which the frame disruptions disrupt a SCOP protein structure domain (P < 0.05), and which are thus unlikely to form a stable functional protein product.
However, by focusing on a population likely to have adapted to a new environment during invasion (Denmark), we have access to the adaptation filter on phenotypic evolution and uncover additively behaving traits (intermediate expression in hybrids) in the subset of transcripts that are the most differentially expressed.
Although the use of three different libraries increased the number of novel transcripts identified, there were significant differences in the subset of transcripts detected in each library.
There were significant differences in the subset of transcripts detected in each library [ 33], and the libraries that did not include larger transcripts were clearly superior in detecting sRNAs.
We next compared levels of total Hes1 transcripts in subsets of thymocytes (Fig. 1C).
Transcriptome analysis shows that the majority of protein-coding genes in mammals undergo AS whereby the same sequence belongs to an exon in one subset of transcripts of the given gene locus and to an intron in another subset of transcripts (Blencowe 2006; Kim et al. 2008).
We and others have noticed a bias for cytosine and guanine at the third position in a subset of transcripts within a single organism.
The enrichment of PCBP binding motifs in the subset of transcripts that increased at low body temperature, together with the increased PCBP3 abundance in winter, suggest a role for PCBP3 in protecting a subset of BAT transcripts via its binding to the 3′ UTR C-rich motifs during torpor.
In the subset of transcripts showing differential basal expression at both time points, about 75% were more strongly expressed in V. vinifera and about 25% were more strongly expressed in V. riparia.
Because the mutations affect only exons incorporated in a subset of transcripts or affect splicing (which can be leaky) and because of embryonic lethality in mouse and chick with homozygous null mutations, we speculate that humans surviving with KIAA0586 mutations may retain partial function.
