When the same IP screening tool is used on multiple encounters at WCVs, changes in subsequent responses and risky behaviors can be assessed.
Langerin/OVA combined with imiquimod could not prime CD8+ T cells and resulted in poor cytotoxicity in subsequent responses.
Similarly, the first, negative voltage response to a dim step will be enhanced because more microvilli will be in an inactive state than in subsequent responses, because initially many are still refractory [ 41].
This contrasts with observations from the current study that improvement during run-in predicted subsequent response to placebo, but not to active treatment.
Therefore, macrophage reprogramming via a particular signalling pathway that leads to an increased activity or content of this protein results in an increase in the subsequent response of the macrophages to the ligands of another pathway.
To investigate how spatial anisotropies during mitochondrial permeabilisation and cyt-c release reflect in the subsequent response of cytosolic effector caspase activation we performed an in silico analysis of the signalling dynamics using a spatial systems model.
It is believed that sustained activity of neurons during adaptation causes a shift in their subsequent response level, leading to increased sensitivity to opposite (or complementary) stimulus attributes [14].
Analysis of 14 dehydration response genes after multiple stress treatments revealed the existence of two different types of transcriptional responses: genes that produced transcripts at similar levels during each stress and genes that in a subsequent response significantly increased their transcript levels and transcription rates relative to the first response [ 9].
Although the flavones did not themselves induce changes in CD11b, the subsequent response to fMLP-induced CD11b was unchanged with apigenin (Supplemental Fig. S1 D), reduced with luteolin (Supplemental Fig. S1 E), and increased with wogonin (Supplemental Fig. S1 F).
