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Studies performed thus far did not address conclusively whether bevacizumab should be continued in subsequent lines of treatment.
The column headed -ln L gives the log-likelihood of the best tree in the first line and the differences in log-likelihood of the other trees in subsequent lines.
Due to lack of available data on the amount of use of post-progression treatments from PRONOUNCE (number of cycles, combination regimens), all intravenous systemic therapy in subsequent lines was assumed to be for three cycles and administration costs were applied for each component individually.
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(2) Three studies show a dominance of erlotinib when compared to docetaxel in subsequent-line settings.
In some situations, OS is no longer a reliable endpoint, e.g. in advanced colorectal cancer treated in the first line, mainly because of the increasing availability of effective agents in the subsequent lines [ 33].
EGFR-TKIs were given as front-line therapy in 29 patients including 26 EGFR mutated patients, and in second or subsequent lines of therapy in 70 individuals, including 29 EGFR mutated, 16 KRAS mutated and 25 triple negative.
Despite the growing number of options in first and subsequent lines, most patients develop resistance to these therapies [ 2].
Sixteen patients received platins-pemetrexed as first-line treatment for NSCLC and 46 received pemetrexed as monotherapy in second and subsequent lines.
Several patients in our series received subsequent lines of chemotherapy, in most cases trabectedin and gemcitabine.
'Initial antibiotic treatment modification' was defined as a change in initial antibiotic treatment due to insufficient response, adverse reaction, interaction with other drugs, non-suitability of the initial antibiotic based on the results of microbiological tests or changes to or addition of new agents in a subsequent line, alone or in combination.
Vinflunine was predominantly administered as second-line (66%%) therapy or in subsequent treatment lines (21%%).
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