Studies performed thus far did not address conclusively whether bevacizumab should be continued in subsequent lines of treatment.
The column headed -ln L gives the log-likelihood of the best tree in the first line and the differences in log-likelihood of the other trees in subsequent lines.
Due to lack of available data on the amount of use of post-progression treatments from PRONOUNCE (number of cycles, combination regimens), all intravenous systemic therapy in subsequent lines was assumed to be for three cycles and administration costs were applied for each component individually.
(2) Three studies show a dominance of erlotinib when compared to docetaxel in subsequent-line settings.
'Initial antibiotic treatment modification' was defined as a change in initial antibiotic treatment due to insufficient response, adverse reaction, interaction with other drugs, non-suitability of the initial antibiotic based on the results of microbiological tests or changes to or addition of new agents in a subsequent line, alone or in combination.
Six patients had epidermal growth factor receptor (EGFR) mutation, and they all were treated with gefitinib in a subsequent line.
Similarly, an analysis of an integrated database of electronic medical records from 91 oncology practices indicated that among 1106 patients who received bevacizumab-containing regimens for metastatic colon cancer, 280 (25%) received it beyond progression in a subsequent line [ 8].
Axial positions of the imaging plane were visualized by a side-view of subsequent line scans in a Fluorescein solution at different axial positions (Fig. 2a ).
All patients receiving cetuximab in the second or subsequent line were refractory to previous regimens.
After the key-word delimited top section of the file, use the keyword "runs" (or "files", with or without ":") to denote that subsequent lines in the file should be interpreted as runs.
After the key-word delimited top section of the file, use the keyword "runs" or "runs:" to denote that subsequent lines in the file should be interpreted as runs.
