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These studies demonstrate high degrees of neuroprotection in stroke with EPO when the neurotrophin is re-engineered as an IgG EPO fusion protein to enable transport across the BBB following IV administration.
There was better awareness of oxygen use in stroke, with 41% answering correctly compared with 18% in MI.
They did, however, identify a reduction in stroke with aspirin for women with diabetes (RR 0.45, 95% CI 0.25 0.82) (17).
The very large Women's Health Initiative study [ 60] showed no significant difference in stroke with treatment (calcium and 200 IU vitamin D3 twice daily) versus placebo.
Inter-subject differences in swallowing patterns are more overt in stroke, with the majority of chronic dysphagic patients requiring artificial feeding to retain nutritional levels.
Neurological PEA levels in human stroke patients are increased following ischaemia (Schabitz et al., 2002), which suggests a protective role for PEA in stroke, with permeability-reducing effects on the BBB potentially forming part of this.
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8 On the other hand, a systematic review of 26 studies found a 20% reduction in strokes with statin therapy compared with placebo or usual care.
These results are consistent with the category-specific pattern observed in stroke patients with lesions in this same region [ 18].
There was an increase in stroke risk with surgery, but that was outweighed by fewer deaths and heart attacks.
The effects of lingual exercise in stroke patients with dysphagia.
Prediction of walking function in stroke patients with initial lower extremity paralysis: the Copenhagen Stroke Study.
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