In spite of some specific challenges for pathway-based analysis of the massive but more informative sequence data (see the previous review by Wang et al. [53]), NGS data would provide golden opportunities to expand the capacity and power of pathway-based analysis or gene set analysis in general to formulate and test the global hypothesis on disease susceptibility.
"In spite of some bad press and the challenges ahead, the word for what we are planning has started to trickle out," he wrote.
In spite of these challenges, some strong and consistent associations between triple negative or basal-like breast cancer and demographic variables are emerging, and there are hints that prevention strategies for this aggressive subtype of breast cancer may also be attainable.
In spite of these challenges and some regulatory unknowns, we anticipate that PAGE will be a widely used and accepted technology within the foreseeable future.
In spite of-and perhaps strengthened by-numerous challenges, she has forged a path illuminated by creativity and generosity.
"Most of our agenda has now been passed by the House — and in spite of the challenges of divided government, some of it has been enacted into law," he said.
Why did belief in the gods persist in spite of critical challenges?
But in spite of the challenges it faces as a developing country, Mexico is one of the chief economic and political forces in Latin America.
Iran's standing is stronger in spite of its challenges at home, with a troubled economy, high unemployment and a determined political opposition.
