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The phrase "in spite of lacking" is grammatically correct and can be used in written English.
It is typically used to express a contrast between two things, one of which is lacking or deficient in some way. Example: In spite of lacking financial support, the small non-profit organization was able to make a significant impact in the community. In this sentence, "in spite of lacking" is used to show that the non-profit organization was able to achieve success despite not having enough financial resources.
Exact(12)
She chose the Macclesfield lab for the simple reason that it was close to her home and, in spite of lacking insurance cards, managed to land the job.
The first is a young English field security officer, Will Walker, a model of Anglo-Saxon attitudes: stiff upper lip in spite of lacking the "look of the officer class", thinking he can stop someone from shooting with an "I say!", introducing himself as a fellow "from the Midlands, Shakespeare's country".
By the mid-1970's Archie has married again, this time to a six-foot Jamaican teenager named Clara, a beauty in spite of lacking her top row of teeth; they have a daughter, Irie, who will become the steady center of the narrative.
However, the proposed TG model provided substantially good estimates of ecosystem WUE in spite of lacking skills in monitoring summer troughs.
In spite of lacking the β-glucosidase activity the gene showed significant similarities with family 3 enzymes and this family is highly conserved as it includes β-glucosidases only.
PhBPL in spite of lacking repressor function does exist as a dimer.
Similar(48)
The main advantage of the proposed index is that, in spite of lack of a reference data set, the global quality of a fused image can be assessed at the full scale of the PAN image.
In spite of lack of knowledge lively debates on these visionary technologies emerged – and obviously, this field of futures reflections is beyond the scope of the mode 2 approach.4.4
Good news: If they can function well in spite of lack of sleep, so can we.
Nevertheless, in spite of lack of genetic support, biochemical classification into biovars is still uncritically used.
They accepted that uncertainty is an inherent part of their profession and realized that they often have to decide in spite of lack of scientific knowledge.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com