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In spite of certain borderline cases, it normally stands in direct contrast to written literature.
In spite of his basic acceptance of traditional views on numbers, the solution of certain problems led Cardano to consider more radical ideas.
In spite of various methodological problems and certain inherent limitations of epidemiological studies, they can, when properly conducted, make significant contributions to knowledge of disease etiology and provide the means of reducing the risk of a disease, even when its etiology is not completely known.
On balance, in spite of its problems, I have become a convert to used clothing.
In spite of these problems, the rhododendron has been spectacular this year.
"I am confident entrepreneurs will find a way to do business -- profitable business -- in spite of electricity problems, water problems, real problems.
Mr. Scharffenberger maintains that in spite of these problems, the company is well poised for the future.
He said: "There is fortitude and joie de vivre here - the ability to celebrate life in spite of many problems".
In spite of the problems, Mr. Matera, for one, believes that real estate is a safer investment than stocks.
In spite of these problems, it is worth working there.
In spite of these problems, three major outcomes can already be identified.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com