We have chosen the protein decoy path because, if a certain degree of specificity can be assumed between a chemokine and its GAG ligand [ 25], CXCL8 should have a built-in specificity for its GAG ligand.
We have used our molecular model of a CXCL8 heparin complex [ 13] to prevent interfering with hydrogen bonding and hydrophobic interactions in our mutagenesis protocols in order to keep the chemokine's built-in specificity for a well-defined GAG ligand.
No false positive results were obtained in any test resulting in specificities of 100% for the PCR assays.
Adding intracellular (liver-specific) MRI contrast agents provides a significant improvement in early detection and in specificity for HCC.
Digital Breast Tomosynthesis (DBT) offers a gain in sensitivity and in specificity for detection of breast cancers compared to 2D mammography, due to tissues' overlapping reduction.
Digital Breast Tomosynthesis (DBT) offers a gain in sensitivity and in specificity for the detection of breast cancers compared to 2D mammography, due to reduction of the tissues' overlapping.
Nearly half of the AKRs are expected to be monomeric, but there are examples of dimeric, trimeric and octameric enzymes, as well as diversity in specificity for NAD as well as NADP as a cofactor.
However there was no significant difference between readers in specificity for any of the methods.
It is noticeable that chAb 18B7 has an overall lower binding reactivity for the self-Ags used in this study, in accordance with differences in specificity for this Ab with respect to mAb 18B7.
So, what is gained in specificity for microarray oligo-design is lost for gene annotation.
These structural differences suggest potential differences in function, including differences in specificity for DNA-dependent activation.
