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Although a growing appreciation of the importance of miRs in cancer biology is emerging, much remains to be learned about their roles in specific regulatory programs.
However, the role of 5hmC in specific regulatory regions is not clear, especially at enhancers.
While overall tubulin expression is carefully controlled, most eukaryotes express multiple tubulin genes in specific regulatory or developmental contexts.
Thus, whether these two miR156 family members play a dominant role in specific regulatory pathway in both plants requires further investigations.
It is currently unclear whether these species are merely reaction intermediates along the demethylation pathway, or whether they participate in specific regulatory functions in the cell, possibly by recruiting dedicated binders.
The use of genomics methods to identify alterations to T cell states in human disease conditions and the identification of polymorphisms affecting transcription factor binding, will allow us to link pathology to changes in specific regulatory mechanisms.
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The restricted pattern of expression of pBRP2, which is similar to that of some TBP-related factors in animals, is unlike that of other B-factors characterized to date in eukaryotes, suggesting that it participates in a specific regulatory process.
In addition, specific regulatory and ethical issues must be considered when performing clinical research in children.
The purpose of this paper is to discuss the challenges associated with using CFD in this specific regulatory context.
This approach may uncover modules active in a specific regulatory network (i.e., transcriptional regulation of a gene) that may otherwise go undetected using current computational methods.
Absolute conservation will be relatively rare because of the earlier noted variability in the specific regulatory associations.
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