Furthermore, recent evidence in patients with NSCLC points to a specific gain in function in patients who bear somatic mutations in the tyrosine kinase domain of the EGFR (Lynch et al, 2004; Paez et al, 2004).
Our analyses are limited, therefore, in distinguishing between rapid lineage specific gains in zebrafish and excessive gene loss in other teleosts for particular duplicate sets.
The organization and depth of students' exams (in-class essays) also improved, with specific gains in their use of scientific evidence to defend their arguments.
(2006) showed that the incidence of a specific gain-in-function polymorphism of the NLRP3 gene was significantly higher in hypertensive than normotensive individuals.
In S. hirsutum, a lot of specific gains occurred in a particular gene copy, Stehi1|78757|, which has probably a quite different history.
Thus, while there appears to be an avian-specific loss of two repressive domains in FOXE1 as a result of deletions, we also found an avian specific gain in proline-alanine repeats, which can potentially confer transcriptional repressive activity to avian FOXE1.
In summary, our study demonstrates an example of predicting the treatment effect of mexiletine in patients suffering from a specific gain-of-function mutation in NaV1.7.
The GAERS Cacna1h missense mutation results in a splice-variant specific gain-of-function of Cav3.2 currents that exhibit significantly faster recovery from channel inactivation and greater charge transference during high-frequency bursts6.
Because GHR spans and combines multiple disciplines, it is challenging to attribute specific gains in a specific discipline through the actions of a GHR team.
This massive loss of methylation often suggests the acquisition of plasticity and de-differentiation associated with stem cells (Fig. S2A), together with specific gains in promoter methylation (Fig. S2B).
