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So we have now identified in CtxB, amino acids which are involved in some association steps, unshared with LTB.
It should be noted that there are inherent limitations in some association studies that are related not to sample size but to intrinsic heterogeneity of disease phenotype.
In some association studies, such as those that use random effect models for example, the only input that differs from one AIP to another is the similarity (covariance) matrix built for the tested location.
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The stability ranges of micas have been investigated in the laboratory, and in some associations their presence (as opposed to absence) or some aspect of their chemical composition may serve as geothermometers or geobarometers.
Third, information on relevant variables such as pharmacological treatment, duration or severity of headache is not currently collected by the Spanish National Health Survey which may act as confounding factors in some associations.
"It can be dealt with retrospectively by disciplinary committees - it is done so in some associations - and I believe that is the correct thing to do," added the 68-year-old from Northern Ireland.
Where significant associations appear in the Dutch dataset without a comparable association in the smaller Malta dataset, this was reflected in some associations losing significance in the combined dataset (for example "vomiting" in the case of pyelonephritis).
There were no associations between quintiles of hospital planned caesarean section rates and morbidity outcomes, but four outlying observations resulted in some associations between quintiles of hospital intrapartum caesarean section rates and morbidity outcomes.
Our study was underpowered to detect associations of RBP4 single nucleotide polymorphisms with GDM, probably because of their low frequencies, which may have resulted in some associations being overlooked.
Third, the number of pre-menopausal women might have been insufficient for the purpose of detecting significant differences in some associations, such as the dose response curve for adult weight gain.
Furthermore, our sample corresponds to the screening programme target population (women aged 45 68 years), so that the number of pre-menopausal women might be insufficient for the purpose of detecting significant differences in some associations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com