Sentence examples for in smaller phase from inspiring English sources

Opn4 knockdown resulted in smaller phase delays compared with the control injected with a non-targeting siRNA (reduced to 50%).

Most other TKIs so far have either only been tested in smaller phase I and II studies, or have failed to show meaningful effects in larger randomised phase III studies (Koehne et al, 2006).

Few recent AD programs have followed this model, with sponsors tending to commence a full phase III program after seeing evidence of target engagement biochemically in smaller phase II studies.

Because there are no pharmacotherapies that have been proven to alter clinical endpoints (dialysis, mortality) in patients with ARF, it cannot be discerned what changes in currently available serum GFR markers (urea, creatinine) are predictive in smaller phase II studies of success in subsequent phase III trials with clinical end-points.

He suggested releasing Amalur in smaller phases, rather than "trying to build the skyscraper horizontally and then standing it up".

TIL-based therapies have only been offered in small phase I/II studies in a few centers given the highly specialized care required, the complexity of TIL production and the very intensive nature of the three-step treatment protocol.

In small phase I/II studies each with 25 patients, escalation of TBI combined with cyclophosphamide plus fludarabin resulted in further improvement in response rates to up to 72%, with 10 20% of patients acquiring a durable complete response.

Paclitaxel has been extensively studied in melanoma and objective response rates in the first-line setting have ranged from 0 to 16% in small phase II trials (Einzig et al, 1991; Aamdal et al, 1994; Bedikian et al, 1995).

A number of other chemotherapeutic agents, including irinotecan, paclitaxel and amrubicin, have shown some activity in small Phase II/III trials when used as monotherapy or in combination with other cytotoxic agents.

Each of these vaccines is being studied in small phase I trials that enroll HIV-infected persons who are being treated with highly effective antiretroviral therapy and who have a stable clinical course and no detectable plasma viremia.

Complete responses have been reported in 15 100% of patients and appear to depend on severity of GVHD, specific organ involvement, timing of therapy, previous and concurrent therapy, and other patient-specific factors that cannot be controlled for in small phase II or retrospective studies (23).