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The first one, Mr. Hale said, which has already shown some promise in small trials, could reach the market in 2008 or 2009.
[15] recommend investigation in small trials, before entering larger clinical trials, when introducing new orthopaedic products.
Although the effect of levocarnitine therapy on uremic anemia has been studied in small trials, its effects on cardiac function remain unclear.
Although the effect of intravenous levocarnitine therapy was studied in small trials, the effect on global outcomes in larger populations is unclear.
The drugmaker also is testing Viagra in women, and it has a chemical in the same class as Viagra in small trials in England.
ROR<1 indicated larger beneficial effect in small trials.
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If it works – and it has been successful in smaller trials – it will cut the length of a course of pills for TB from six months to four and for MDR-TB from 18-24 months down to six months.
Instead, once safety was generally shown in smaller trials, sponsors would get marketing approval and then could collect such evidence through follow-up studies of customers once they were also collecting revenue.
Bias is unlikely to be a major issue as this is a randomised trial, although in smaller trials important random variations between arms can occur.
In smaller trials provision of an opportunity to enter free text should be considered.
Overestimation of the treatment effect is more likely in smaller trials compared with larger samples.
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