Further study is required to optimize the cohesiveness and clinical effectiveness of PP as an in situ setting temporary embolic agent.
We evaluated the mechanical and histomorphological repair process of caprine subchondral femoral defects augmented with either a bioresorbable in situ setting hydroxyapatite cement (HAC), polymethylmethacrylate (PMMA), autogenous bone graft (AG), or left empty.
Potential benefits of the CPC-stem cell paste include injectability, intimate adaptation to complex-shaped bone defects, ease in contouring to achieve esthetics in maxillofacial repairs, and in situ setting ability.
Moreover, these results illustrate that simulating the GBM microenvironment in vitro has the potential to identify novel targets for radiosensitization (i.e., those not suggested from standard culture conditions) applicable to an in situ setting.
In situ setting hydroxyapatite cement may be a viable alternative for the repair of subchondral defects with an important advantage that while undergoing gradual resorption and replacement with host bone, mechanical integrity of the skeletal defect is maintained.
Native tissue preparations represent a model in which individual cells are in histo-anatomical conditions close to the in situ setting, but where targeted intervention and observation at the cell-level are more difficult.
