The data collected in healthy controls allow a classification of finding in single patients.
The aim is to allow a systematic psychoacoustic evaluation of complex sound processing in single patients.
One troubling reason for this is that research so far seems to indicate that specific genetic abnormalities associated with autism risk are extremely rare, with many being found only in single patients.
Immunoselection of antigen-loss variants was observed in single patients after the induction of strong antigen-specific CD8 + T cell responses in vivo.
An early study with 12 patients using [11C]PK11195 showed some increases in focal binding in brains of MS patients and described a certain overlap to signal changes in the MR in single patients [1]; however, the regional analysis in this study was limited as only the brainstem and thalamus have been evaluated.
Cancer type Mutation/tumor Respiratory/lung cancer 200 300 Skin/melanoma 100 200 Esophageal/colon cancer 50 100 Pancreatic, ovarian 30 60 Breast 20 70 Hematopoietic cancer 1 10 (CML/AML/ALL/CLL) rhabdo/myo/sarcoma 1 3 Mutations of tumor cells were based on means of mutation in single patients (CML/AML/ALL/CLL) Soft tissue/rhadomyoscarcoma.
Moreover duplications at 15q13.3 and at 16p13.11 were found in single patients (Table 2).
For the SLC10A2 gene only a few dysfunctional mutations were identified in single patients diagnosed with Crohn's disease, hypertriglyceridemia and/or in patients with different forms of bile acid malabsorption [28], [31], [35], [36].
In the group of patients with as well as without pusher syndrome, we found only few voxels in single patients (dark blue colour in Fig. 2 indicates malperfusion in n = 1 subject) to be malperfused though structurally intact.
In contrast, IgE autoantibodies, such as those detected in about 50% of csU patients in our study, have not been described as relevant for the activation of mast cells in csU, except for in single patients.
Moreover, the real-time experimental identification of a given phenomena based on real-time power imaging in single patients can lead to the design of systematic investigations with non-invasive imaging techniques (e.g. EEG, MEG) allowing for a more exhaustive spatial sampling of the task-related activations and the detection of large-scale functional networks.
