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CRCs display at least two types of genomic instability: chromosomal instability (CIN) associated with mutant Apc and p53 and giving rise to aneuploidy, and microsatellite-instability (MSI) caused by defective DNA mismatch repair (MMR) and resulting in mutations in simple sequence repeats (SSR) throughout the genome [5], [6].
Mycobacteria are especially prone to polymerase slippage in simple sequence repeats, for two reasons.
We have demonstrated unexpected secondary higher-order structure in "simple sequence" DNA.
This table shows the position of interruptions in simple sequence repeats.
Bm and Bp further diverged from each other in a small number of genes resulting from unit number changes in simple sequence repeats (ssr) in the homologs.
The mutation rate in simple sequence repeats is much higher than in non-repeated sequences [ 8, 9], and increases with the number of repeats [ 7, 10- 13].
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The five dancers — Mr. Jasperse, Michelle Boulé, Levi Gonzalez, Eleanor Hullihan and Kayvon Pourazar — wound through the thicket in simple sequences based on half-pivots that looked like Mr. Jasperse's crocheting gestures at the start.
Stimuli were presented in simple sequences during the entire experiment.
Another major interest in simple sequences stems from the observation that they constitute an important source of genetic (and possibly phenotypic) variation [ 14].
The dominance of Asparagine in SSPs of species of low GC mirrors the trend observed in the low complexity sequences of Plasmodium falciparum, an AT rich species [ 32] and points to an early tendency of abundance of Asparagine in simple sequences.
The functions of the genes with low-complexity sequences appears to differ between P. falciparum and previously studied eukaryotes in which genes involved in processes such as development or transcription were found to be enriched in simple sequences (Alba and Guigo 2004; Faux et al. 2005; Huntley and Clark 2007).
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