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Because the interacting proteins are more likely associated with similar cellular processes and/or involved in similar function, this similarity measure is higher for functionally related proteins, and vice versa.
The idea is that if two domains are associated with similar cellular processes and/or involved in similar function, they are more likely to interact.
The nature of our screening approach meant that many of our predictions overlapped extensively in similar function categories.
The idea is that the interacting proteins are more likely associated with similar cellular processes and/or involved in similar function.
At the same time, a number of experimental studies suggest that while sequence might encode enough information to drive TF binding [ 15], the way this information is encoded is not trivial – similar sequence does not necessarily translate in similar function and vice versa.
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Furthermore, to investigate the hypothesis that certain QTL regions may contain several genes involved in similar functions associated with arthritis, we studied functional connections between genes within collagen-induced arthritis QTL regions from two different rat crosses.
Bacterial genes involved in similar functions are often organized into operon structures.
Since orthologous genes are likely to be involved in similar functions in mice and humans, we also expect their width of expression to be similar.
In neurodegenerative diseases, it is still a mystery that neurons in similar functions start to degenerate simultaneously regardless of their spatial location in the brain.
Most of these conserved DDIs are either homotypic, or those occurring between domains involved in similar functions even if they are heterotypic.
GPBS is also involved in similar functions in F. oxysporum[ 39].
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