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Both prior infection and vaccination conferred nearly complete protection in the lungs, however, only prior infection resulted in significant protection in the upper respiratory tract.
The effectiveness of the matrix mutant treatment proved to be CD8+ dependent and directed against tumor antigens other than gp33 since adoptive transfer of isolated CD8+ T lymphocytes from treated B16gp33-bearing mice resulted in significant protection of naive mice against challenge with the parental tumor.
This resulted in significant protection from lethality.
PVG alleles in Eae23 resulted in significant protection from EAE and attenuated CNS inflammation/demyelination.
Oral administration of CDDO-MA resulted in significant protection against MPTP-induced nigrostriatal dopaminergic neurodegeneration, pathological alpha-synuclein accumulation and oxidative damage in mice.
Immunization with Her2MPtVLPs and CpG as long as ten weeks before challenge still resulted in significant protection compared to unimmunized mice (60% protection, p<0.01) (Table 2).
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In contrast, these concentrations of oxaliplatin had no effect on clonogenicity of HCT116 p53−/− cells, further demonstrating that inactivation of p53 in colon cancer cells results in a significant protection from oxaliplatin cytotoxicity.
In Parkinson's disease, the treatment with creatine resulted in a significant protection against both CNS dopamine depletion and neuronal loss in the substantia nigra [ 24].
Another study demonstrated that B. anthracis glyceraldehydes-3-phosphate was predominantly interacted with plasminogen and that immunization with the recombinant protein resulted in a significant protection upon challenge with B. anthracis in the murine model [25].
In addition, significant protection was achieved after challenge (lower parasitemia in comparison to unvaccinated group) [ 157].
As shown in Figure 3A, vaccination with pcDNA3.1-VNTR resulted in a significant protection compared to the empty vector and PBS (P < 0.0001 by one-way ANOVA).
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