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"A major signalling problem in the Weybridge area on Monday resulted in severe disruption," he said.
At least 200 of the 450 of homes on Rota were destroyed and the remainder were damaged; 95% of the power poles fell across the island, resulting in severe disruption to daily life.
The scattershot (sctt) mutation results in severe disruption of germ cell migration [22].
Maternal/zygotic baz mutants fail to properly position AJs prior to gastrulation resulting in severe disruption of epithelial structure and morphogenesis [19], [24], [54].
Mass disasters cause widespread and severe damage, injury and loss of life or property, resulting in severe disruption of daily activities and infrastructure.
The dispersion of ash in the atmosphere over large distances can result in severe disruption to aviation (Miller and Casadevall 1999; Eurocontrol 2010), and sedimentation of ash can be hazardous to populations (Baxter 1999; Wilson et al. 2012).
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Mutations in the first category of genes result in severe disruptions specific to meiosis, without documented effects on non-meiotic functions [ 26, 27].
Water loss in this matrix results in a severe disruption of cell wall integrity, which can be irreversible [ 33].
Blockade of either Dab1 or Pi3K resulted in continued severe disruption of vimentin+ processes in the presence of reelin whereas BLBP+ processes were unchanged compared to controls (slices cultured in plain medium or cocultured with control HEK cells) (Figure 4G H,J).
This is of importance because axial mesodermal cells arrest the cell cycle after involution [28], and if they are forced to proliferate, this results in a severe disruption of gastrulation [20] [22].
Experimentally reducing MuRF3 expression during myocyte development results in a severe disruption of sarcomeric Z and M-band formation, likely due to these effects on tubulin dynamics [ 7].
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Justyna Jupowicz-Kozak
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