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44 Brimonidine tartrate has been evaluated in patients with moderate to severe erythema of rosacea in several Phase II and III clinical trials (Table 1).
It has been investigated in several Phase I and Phase II Clinical Trials as an anti-cancer drug [ 49- 52].
At the moment, the company is in several Phase I trials with CG53135, which has shown promise in treating some of the side effects of radiation and chemotherapy.
APO866 is currently in several Phase II clinical trials to evaluate its efficacy in controlling cancer growth.
In several phase III clinical trials in advanced NSCLC, the combination of platinum with taxanes attained median survival times of 8 11 months and 1-year survival of 31 46%[3].
Duloxetine was further evaluated in several phase 3 trials.
TG101348 is also in several phase II studies for hematopoietic neoplasm (www.clinicaltrials.gov).gov
Myalgia was the dose-limiting toxicity in several phase I human trials.
These approaches have been evaluated in several phase I/II clinical studies.
Different oxaliplatin/gemcitabine (Gemox) combination regimens were assessed in several phase II clinical trials.
This has extensively been explored in several phase I and II studies.
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