Changes observed in intermediary metabolism described effects in several pathways of liver energy metabolism due to naphthalene.
Given that mitochondria are key players in several pathways of programmed cell death (see above) many strategic battles regulating cell death resistance take place in mitochondria [49].
The ligand-receptor complex IL-22/IL-22R IL-22/IL-22R IL-22/IL-22Ral playsays especially in the regulation and resolution of immune responses.
Akt also is involved in several pathways that promote cell survival and antiapoptotic effects through inhibition of FOXO3a, inactivation of GSK3β, induction of XIAP, inactivation of caspases, and prevention of cytochrome C release (Figure 2).
While the primary role of this pleiotropic hormone is regulation of calcium metabolism, it also plays a key role in several pathways of the innate immune response system, controlling cell growth, differentiation and apoptosis [1], [2].
Functional annotation of this bicluster suggested its role in several pathways studied in neuronal systems.
Furthermore, proteins that participate in several pathways can implicate multiple biological processes with a single ADR.
These genes were involved in several pathways regulating e.g. neuronal damage, Ca2+ homeostasis, glial reactivity, inflammation, and synaptic transmission.
DAPk is involved in several pathways leading to cell death, including apoptosis, autophagy and anoikis-like cell death.
The abundance of enzymes involved in several pathways related to amino acid metabolism (e.g., arginine metabolism) and oxidative stress response differed in MF and FF animals.
We have analyzed expressions of only a few genes while Hog1p and Calcineurin together regulate expression of a wide number of genes involved in several pathways.
