Severe mitochondrial disorders also lead to a very short life expectancy in several organisms.
Gene-drive systems developed in several organisms result in super-Mendelian inheritance of transgenic insertions.
Antimicrobial peptides (AMP) have been widely described in several organisms from different kingdoms.
These tools rely on diverse mechanisms and exhibit activity in several organisms.
This is an attractive idea considering NMD has been shown to degrade unproductive spliced or aberrant transcripts in several organisms including C. elegans51, S. cerevisiae52,53, and Drosophila54.
Studies in several organisms have shown that eukaryotic centromere regions contain proteins involved in chromosome inheritance functions such as centromere structure, heterochromatin assembly and sister chromatid cohesion.
The Cas9/sgRNA complex can efficiently generate site-specific double-strand break (DSB), resulting in the activation of the DSB repair pathway, as demonstrated by previous studies in several organisms.
Consequently, the MLE has been expressed in several organisms.
Antimicrobial peptides (AMPs) represent the first line of defense against pathogens in several organisms (Hancock and Lehrer 1998).
The immune system is a sensitive target to the toxic action of chemicals in several organisms [19, 30 32].
Based on studies in several organisms, we speculate that carnosine exerts these apparently opposing actions by affecting energy metabolism and/or protein homeostasis (proteostasis).
