1. Aravind L, Mazumder R, Vasudevan S, Koonin EV: Trends in protein evolution inferred from sequence and structure analysis.
The pipeline is built by incorporating network-based analysis of the protein protein interactions, a flux-balance analysis of the reactome, phenotype-essentiality data derived from experiments, targetability assessment based on sequence and structure analysis using in-house novel algorithms.
Hence the special importance of advanced methods for sequence and structure analysis in virus discovery.
Taking advantage of our experience in antibody sequence and structure analysis (Chailyan et al., 2011; Ghiotto et al., 2011; Marcatili et al., 2013), we developed Tools for AntiBody Humanization (Tabhu), a comprehensive platform meant to help antibody humanization experiments.
Topics include original research (both theoretical and experimental) in comparative genomics, sequence and structure analysis, molecular evolution, proteomics, gene expression, transcriptional regulation, biological networks, drug discovery, and privacy.
In essence all the sequence and structure analysis was performed using publically available programs, which have been published and are well-known in the computational biology community, if not more widely.
In this study, using sensitive sequence and structure analysis, we provide evidence for the origin of the ALOG domain from the N-terminal DNA-binding domains of integrases belonging to the tyrosine recombinase superfamily encoded by a distinct type of DIRS1-like LTR retrotransposon found in several eukaryotes [ 23].
Similarly, MAEBL ligand domains and AMA1 ectodomain sequence and structure analysis comparison suggests a role in similar steps in the invasion of host cells [22].
Adekoya, O. A., Helland, R., Willassen, N. P. & Sylte, I. Comparative sequence and structure analysis reveal features of cold adaptation of an enzyme in the thermolysin family.
Alva, V., Nam, S. Z., Söding, J. & Lupas, A. N. The MPI bioinformatics Toolkit as an integrative platform for advanced protein sequence and structure analysis.
Analysis of 15 T. brucei BESs revealed striking similarities, both in sequence and structure (Hertz-Fowler et al., 2008).
