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These differences likely contribute to the difference in sensitivity to neutralization.
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As illustrated in Figure 1 different viruses showed a differential sensitivity to neutralization by the various Mabs and sCD4.
Of the four patients (ITM60, NYU104, 3506 and ITM27) whose sequential viruses exhibited increased sensitivity to neutralization by anti-V3 mAbs, those from patient ITM27 exhibited the weakest increase in neutralization sensitivity (Figure 2h).
Four of the five patients' viruses evolved increased sensitivity to neutralization by anti-V3 mAbs.
Primary HIV or SHIV strains are classified as tier 1 or tier 2 depending on their sensitivity to neutralization [17].
Information is sparse on the evolution of sensitivity to neutralization of HIV-1 primary isolates by antibodies that either do or don't neutralize viruses tested in cross sectional studies.
According to their sensitivity to neutralization of SF162 with TriMab or 4E10 (Tables 2, 3 and 4) laboratories could be divided into three categories.
The neutralizing activity of the mAbs was initially measured using 20 pseudotyped HIV-1 primary isolate envs characterized by different sensitivity to neutralization [44], [45].
Conversely, antigenic variants may also reduce the strength of antibody binding rendering less sensitivity to neutralization.
Recent studies using HCVpp expressing a panel of glycoproteins cloned from clinical material demonstrate differences in sensitivity to antibody neutralization, in contrasts the most commonly used H77c viral strain was easily neutralized by the majority of sera (Tarr et al., 2011; Osburn et al., 2014).
Changes in sensitivity to some smells.
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