Exact(2)
One group of investigators showed that ganglion cells of the cat differed in sensitivity to a given grating when the sensitivity was measured by the degree of contrast between the black and white lines of the grating necessary to evoke a measurable response in the ganglion cell.
In addition, the sigmoidal dose response curve often produced by quantal data (apical adverse effects) in linear space occurs as a result of the variability in individual responses and underlying genomic plasticity, reflecting differences in sensitivity to a given chemical.
Similar(58)
This allowed us to measure the difference in sensitivity to both classes given different training information.
Second, changes in sensitivity to the concentration gradient of a morphogen could give a similar result.
We used the area under dose response curves (termed as activity area in [ 3]) to evaluate the sensitivity of drug to a given cell line.
Cut-off points for features graded 3 or greater gave a change in sensitivity to 64% (median, range 34 88%) and specificity 55% (median, range 34 82%).
In this context, we predicted that the blockade of 2-AG biosynthesis with the recently developed DAGL inhibitor O-3841 should also result in a greater sensitivity to malonate, given the previously reported neuroprotective effects of 2-AG through its capability to activate both cannabinoid receptors with similar efficacy.
Besides making prediction about the cellular response to drugs, the method identifies critical kinase targets and pathways that are statistically associated to drug sensitivity in a given cell line.
Besides predicting the effectiveness of untested drugs, the KIEN method identifies sets of kinases that are statistically associated to drug sensitivity in a given cell line.
In this paper we show how a plug flow (delay) tank integrated in the recycle path can be used to modify these interactions such as to reduce the disturbance sensitivity in a given frequency range.
Single drug measurements could be used to obtain directly the sensitivity in a given heterogeneous cell population.
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