Positron emission tomography (PET) studies, using the peripheral benzodiazepine receptor PBR28 marker of microglial activation, reported similar variability in the sensitivity of brain microglia to lipopolysaccharide-induced inflammation in baboons (15).
Nonetheless changes in either the energetic requirements of the rewarded response (effort cost) [33], [34] or the time required to perform it (opportunity cost) [38] can produce curve shifts indistinguishable from those due to changes in the sensitivity of brain reward circuitry.
In these fishes, the sensitivity of brain ChE to intoxication by methyl paraoxon is inversely related to the activity of the brain enzyme for ASCho [ 15], in contrast to what was described for trout and rat by Kemp and Wallace [ 16].
In early accounts, increases in dopaminergic neurotransmission were seen to boost the sensitivity of brain reward circuitry [23], [24].
This is in line with previous findings of marked brain dysfunctions in ADHD adolescents despite no stop task impairment (7,8,50) and higher sensitivity of brain activation than behavior to show pharmacologic effects of MPH in ADHD (24,26 28,54,74).
Despite the good sensitivity of brain atrophy, even better results in predicting disability progression have been further achieved by the regional analysis of brain atrophy.
High level of Apaf-1 expression in brain tumors elevates the sensitivity of the brain tumors to apoptosis induced by cytochrome c that reveals that the protein level of Apaf-1 may directly influence the sensitivity of brain cells to apoptotic stimuli.
This review discusses the difficulties in quantifying insulin sensitivity of the brain and why it is vital that we develop technology for this purpose so that we can establish its role in this 'new-age' dementia.
Genetic differences in the CHRNA4 gene seem to change the sensitivity of the brain's acetylcholine system because small structural changes in these receptors make acetylcholine binding more or less likely.
Pretreatment with carbidopa or MAO and COMT inhibitors enhances the sensitivity of [18F]FDOPA brain imaging in Parkinson's disease patients as well as in abdominal tumour imaging [21, 38].
