The mechanistic basis for the selective occurrence of such adduct hotspots in p53 gene is the enhancement of adduct formation by 5-methylcytosine bases present at CpG dinucleotide sequences (Denissenko et al., 1997; Chen et al., 1998; Weisenberger and Romano, 1999; Das et al., 1999; Pfeifer, 2000).
The occurrence of new antigenic clusters results in selective sweeps that restrict strains diversity.
A role for ubiquitin in selective autophagy.
Temperature distribution in selective laser-tissue interaction.
But many engage in selective outsourcing.
These predictors could be used in further research to identify possibilities for selective prevention after occurrence of a family bereavement in adolescents.
Our findings demonstrate the occurrence of selective alterations in A2B AR density and signalling in SSc.
Herein, we report the occurrence of selective increase in methylation at the subtelomeric CpG sites of specific chromosomes in a cohort of glioma patients, which could serve as potential epigenetic biomarker for the disease.
In the literature, occurrence of selective sweeps have been reported in extensively studied organisms for which molecular resources are highly available, such as human [ 49, 50], or Drosophila [ 51– 53], and in domestic species for which directional selection was very strong in the recent history [ 54– 54].
The occurrence of selective sweeps or background selection in ancestral lineages [ 54] cannot be discarded, however it could not be tested with the present data.
In the mitochondrial D-loop sequences, we find several single step mutational derivatives of one of the major mitochondrial haplotypes, suggesting an unusually high mutation rate, or the occurrence of selective sweeps in mitochondria.
