Sentence examples for in selected doses from inspiring English sources

The variation in selected doses reflects the history of investigation of this therapy outside the hemophilia setting, in which there was often uncertainty regarding the dose required for optimal hemostatic efficacy, tempered by early concerns that this treatment could have thrombogenic potential.

Our study highlights the importance of carefully considering the oral dose used in animal experiments and provides useful information in selecting doses for future studies.

Baseline and post-ASA measures included aggregation, slope, and lag time in response to selected doses of 4 known platelet agonists, and urinary excretion of the thromboxane B2 metabolite 11- dehydrothromboxane B2 (Tx-M).

All substances were prepared in corn oil based on repository instructions, with the exception of laboratory 2, which used methyl cellulose; the dose volumes to be administered were calculated based on daily body weights in order to maintain selected doses.

To ensure the effect of this selected dose in different glioma cell lines and to detect the difference of survivin expression levels between tumor and normal cells the same steps were repeated on D54 MG, U251 MG and human astrocytes cell lines.

However, the selected dose resulted in the death of two out of five inoculated hares and it seems that it was close to the LD50 for this mammalian species and the subcutaneous route of infection.

The optimal dosage for iloprost therapy in acute PHT remains unknown, because no dose-response curves are available for this particular situation, but the selected dose and time in our study is within the range reported in the literature for humans [ 15] and pigs [ 47].

Subsequent studies are needed to further titrate the doses to test whether the in vitro-derived FIC indices can serve as a guide to select doses in vivo in order to maximize the benefit of synergy while minimizing the risk of adverse events.

Dose responses of each compound were determined in order to select doses without effect alone.

The first clinical study was designed to provide proof of activity that CC-930 inhibits JNK in healthy volunteers and to select doses for evaluation in IPF patients.

As a result, thoughtfulness must be used in selecting one dose-response function for a QMRA, and the function should be recognized as a significant source of uncertainty.